Donald Metcalf Selected Research

5-hydroxyisourate

9/2010

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.

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Donald Metcalf Research Topics

Disease

13	Neoplasms (Cancer) 01/2017 - 01/2006
9	Inflammation (Inflammations) 01/2020 - 08/2004
8	Thrombocytopenia (Thrombopenia) 03/2014 - 09/2006
5	Leukemia 01/2019 - 05/2006
5	Infections 05/2014 - 01/2006
4	Splenomegaly 01/2014 - 02/2004
4	Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic) 04/2013 - 09/2006
4	Experimental Arthritis 01/2012 - 08/2004
3	Rheumatoid Arthritis 01/2012 - 08/2004
2	Necrosis 04/2014 - 01/2002
2	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2014 - 01/2002
2	Lymphoma (Lymphomas) 01/2014 - 10/2010
2	Down Syndrome (Down's Syndrome) 05/2010 - 09/2006
2	Arthritis (Polyarthritis) 12/2008 - 08/2004
1	Cachexia 01/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016
1	Obesity 01/2016
1	Bites and Stings (Sting) 12/2014
1	Cytokine Release Syndrome 05/2014
1	Human Influenza (Influenza) 05/2014
1	Weight Loss (Weight Reduction) 05/2014
1	Thrombocytosis (Thrombocythemia) 04/2014
1	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 01/2014
1	Histiocytosis 01/2014
1	Lymphadenopathy 01/2014
1	Multiple Abnormalities 01/2014
1	Atrophy 01/2014
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2013
1	Acute Erythroblastic Leukemia (Erythroleukemia) 04/2013
1	Cytopenia 12/2012
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 02/2012
1	Polycythemia (Erythrocytosis) 01/2012
1	Lymphopenia (Lymphocytopenia) 01/2012
1	Hepatitis 01/2012
1	Bone Marrow Failure Disorders 09/2011
1	Infertility (Sterility) 01/2011
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2011
1	Hepatomegaly 09/2010
1	Hepatocellular Carcinoma (Hepatoma) 09/2010
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 05/2010
1	Glomerulonephritis 02/2009
1	Autoimmune Diseases (Autoimmune Disease) 02/2009

Drug/Important Bio-Agent (IBA)

9	CytokinesIBA 05/2014 - 01/2002
7	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2010 - 07/2002
5	Proteins (Proteins, Gene)FDA Link 05/2014 - 05/2006
4	Thrombopoietin (c-mpl Ligand)IBA 04/2014 - 10/2008
3	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2014 - 01/2006
3	Transcription Factors (Transcription Factor)IBA 04/2013 - 09/2011
2	InflammasomesIBA 01/2016 - 12/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2014 - 08/2004
2	Phosphotransferases (Kinase)IBA 04/2014 - 02/2009
2	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 12/2013 - 01/2010
2	Interleukin-6 (Interleukin 6)IBA 01/2012 - 07/2008
1	proto-oncogene protein Spi-1IBA 01/2019
1	Polycomb Repressive Complex 2IBA 01/2017
1	LipidsIBA 01/2016
1	Interleukin-18 (Interleukin 18)IBA 01/2016
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2016
1	CaspasesIBA 12/2014
1	DNA (Deoxyribonucleic Acid)IBA 12/2014
1	Mitochondrial DNA (mtDNA)IBA 12/2014
1	Interleukin-33IBA 05/2014
1	Type I Tumor Necrosis Factor ReceptorsIBA 05/2014
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 05/2014
1	ChemokinesIBA 05/2014
1	Biological ProductsIBA 04/2014
1	Inhibitor of Apoptosis ProteinsIBA 04/2014
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 04/2014
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 04/2014
1	navitoclaxIBA 03/2014
1	Complement System Proteins (Complement)IBA 01/2014
1	Myeloid Cell Leukemia Sequence 1 ProteinIBA 01/2014
1	Interleukin-17 (Interleukin 17)IBA 01/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2013
1	Proto-Oncogene Proteins c-etsIBA 04/2013
1	Interleukin-7 Receptors (Interleukin 7 Receptor)IBA 02/2012
1	EndoglinIBA 02/2012
1	Hemoglobins (Hemoglobin)IBA 01/2012
1	Oxygen (Dioxygen)IBA 01/2012
1	Erythropoietin FDA Link 01/2012
1	Lamin B ReceptorIBA 01/2012
1	Carboplatin (JM8)FDA LinkGeneric 09/2011
1	Contraceptive Agents (Contraceptives)IBA 01/2011
1	Leukemia Inhibitory FactorIBA 01/2011
1	Anti-Infective Agents (Microbicides)IBA 01/2011
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2010
1	Urate Oxidase (Uricase)IBA 09/2010
1	Uric Acid (Urate)IBA 09/2010
1	5-hydroxyisourateIBA 09/2010
1	HydrolasesIBA 09/2010
1	GATA1 Transcription FactorIBA 05/2010
1	Glycoproteins (Glycoprotein)IBA 01/2010
1	Antigen-Antibody Complex (Immune Complex)IBA 02/2009
1	AutoantibodiesIBA 02/2009
1	ethylureaIBA 10/2008

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 12/2013 - 01/2010
3	Therapeutics 01/2019 - 03/2014
3	Transplantation 12/2013 - 01/2010
1	Braces 01/2020
1	Splenectomy 01/2012